Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Can plaquenil help mononucleosis Hydroxychloroquine and lupus nephritis Plaquenil Side Effects of Anxiety and Depression? I've been on plaquenil for a very long time - maybe 15 years. I saw a new rhuemie today who said I should take a break & see how I feel with some anti-inflammatories, a good diet, exercise and rest. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. Tell your doctor if you experience serious side effects of Plaquenil including muscle weakness, twitching, uncontrolled movement, loss of balance or coordination, blurred vision, light sensitivity, seeing halos around lights, pale skin, easy bruising or. bleeding, confusion, unusual. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Side effects of plaquenil depression Depression in Plaquenil how severe and when it was recovered., Rx Side Effects New Plaquenil Guidelines and More. Plaquenil and difficulty breathingPlaquenil homopathChloroquine lysing the endosomeWhat happens when you stop taking plaquenil Less common side effects Skin rashes or changes in skin color; Thinning hair; Weakness; Irregular heartbeat; Mental/mood changes; Arm/leg/back pain; Anxiety; Depression; Ringing in the ears or hearing loss; Worsening of skin conditions If you have psoriasis, Plaquenil may make your condition worse. Talk to your doctor if you have this condition. Rare side effects Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Plaquenil vs. Prednisone Prescription Treatment for.. Plaquenil causing mood changes and depression?. Summary We study how severe was Depression, when it was recovered, drug effectiveness, race, and more among people who take Plaquenil. This study is created by eHealthMe based on reports of 1,993 people who have side effects when taking Plaquenil from sources other than FDA, and is updated regularly. Jul 16, 2018 That’s a very interesting reaction to plaquenil. I was on it for four or five years personally, and did well. But it sounds like you did this correctly. Started off slow. Considered whether the change in your mental state could be related, came off the med and had an improvement. Serious side effects and their symptoms can include the following blurred vision or other vision changes. ringing in your ears or hearing loss. angioedema, or rapid swelling of your skin. hives. mild or severe bronchospasm that causes trouble breathing. sore throat. unusual bleeding or.