One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine lactation category Hydroxychloroquine sulphate tablets usp Can plaquenil cause a rash Dec 04, 2014 Hydroxychloroquine HCQ is an anti-malarial medication that has in recent times been utilized as treatment for a variety of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, and other inflammatory and dermatologic conditions. The majority 90% of physicians screen for hydroxychloroquine retinopathy with either central automated threshold perimetry or Amsler grid as recommended by the PPP. Most survey respondents could not correctly identify the evidence-based risk factors. Pigmentary Retinopathy; Porphyria; Prolonged QT Interval On EKG; Seizures; Skin Rash With Sloughing; Suicidal Behavior; Torsades De Pointes, A Type Of Abnormal Heart Rhythm It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil retinopathy pathogenesis Pathophysiology of diabetic retinopathy., Hydroxychloroquine retinopathy screening How does chloroquine prevent malaria The ocular pathology of autoimmune retinopathy is demonstrated in a 62-year-old female patient with systemic lupus erythematosus SLE who presented with typical clinical autoimmune retinopathy. Macroscopically, there were multiple depigmented lesions. Autoimmune Retinopathy in Systemic Lupus Erythematosus Histopathologic.. Common and Rare Side Effects for Plaquenil Oral. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Ocular symptoms of retinopathy include blurred and partial loss of central vision, side vision and in the later stage, night vision. Symptoms of corneal deposits include haloes and glare. Clinical research has resulted in precise screening protocols and safe dosing guidelines to prevent ocular toxicity and detect retinal damage at an early stage. Rheumatologists use hydroxychloroquine sulfate Plaquenil, Concordia Pharmaceuticals to treat autoimmune diseases, namely discoid or systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, and malaria. When taken at high doses and for long durations, hydroxychloroquine has been known to cause parafoveal retinal toxicity. In fact, the aPL 1st may contribute to the pathogenesis of premature atherosclerosis in SLE, but 2nd they are also the serologic markers of APS, and therefore, of Hughes’ retinopathy. Figure 1 illustrates better the relationships between the most important mechanisms of retinopathy in SLE.