Plaquenil retinopathy pathogenesis

Discussion in 'Canadian Pharcharmy Online' started by SerJK, 02-Mar-2020.

  1. xxxTanya Guest

    Plaquenil retinopathy pathogenesis


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

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    Dec 04, 2014 Hydroxychloroquine HCQ is an anti-malarial medication that has in recent times been utilized as treatment for a variety of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, and other inflammatory and dermatologic conditions. The majority 90% of physicians screen for hydroxychloroquine retinopathy with either central automated threshold perimetry or Amsler grid as recommended by the PPP. Most survey respondents could not correctly identify the evidence-based risk factors. Pigmentary Retinopathy; Porphyria; Prolonged QT Interval On EKG; Seizures; Skin Rash With Sloughing; Suicidal Behavior; Torsades De Pointes, A Type Of Abnormal Heart Rhythm

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Plaquenil retinopathy pathogenesis

    Pathophysiology of diabetic retinopathy., Hydroxychloroquine retinopathy screening

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  3. The ocular pathology of autoimmune retinopathy is demonstrated in a 62-year-old female patient with systemic lupus erythematosus SLE who presented with typical clinical autoimmune retinopathy. Macroscopically, there were multiple depigmented lesions.

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    Ocular symptoms of retinopathy include blurred and partial loss of central vision, side vision and in the later stage, night vision. Symptoms of corneal deposits include haloes and glare. Clinical research has resulted in precise screening protocols and safe dosing guidelines to prevent ocular toxicity and detect retinal damage at an early stage. Rheumatologists use hydroxychloroquine sulfate Plaquenil, Concordia Pharmaceuticals to treat autoimmune diseases, namely discoid or systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, and malaria. When taken at high doses and for long durations, hydroxychloroquine has been known to cause parafoveal retinal toxicity. In fact, the aPL 1st may contribute to the pathogenesis of premature atherosclerosis in SLE, but 2nd they are also the serologic markers of APS, and therefore, of Hughes’ retinopathy. Figure 1 illustrates better the relationships between the most important mechanisms of retinopathy in SLE.

     
  4. LINCOR New Member

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Chloroquine phosphate Pill Images - What does Chloroquine. Chloroquine Phosphate Tablets West-ward Chloroquine Phosphate 250 Mg Tablets
     
  5. Max-min Well-Known Member

    Top 3 Herbs for Polymyalgia Treatment What Is Polymyalgia? Herbal treatment for polymyalgia rheumatica can significantly relieve pain and stiffness. In addition, herbs help to reduce the dosage of corticosteroids or other medicines for PMR. Medicines have so many side effects and provide added burden to the patient.

    Hydroxychloroquine and Colchicine Induced Myopathy The.
     
  6. engence New Member

    Hydroxychloroquine and the eye an old unsolved problem Sir, We agreed with the conclusions of Latasiewicz et al 1 ‘Hydroxychloroquine retinopathy an emerging problem’, which cited cases of hydroxychloroquine HCQ-induced retinal damage. Three patients had received 400 mg HCQ daily for over 15 years equaling 4.93 mg/kg/day in two and 5.6 mg/kg/day in one and all developed maculopathies of varying severity.

    Hydroxychloroquine retinopathy an emerging problem - Eye 31.