Information in these tables is updated regularly.4. Several medications are available for chemoprophylaxis. When deciding which drug to use, consider specific itinerary, length of trip, cost of drug, previous adverse reactions to antimalarials, drug allergies, and current medical history. Plaquenil treatment rheumatoid arthritis Plaquenil toxicity optos Side effects of plaquenil 200 mg Naproxen and hydroxychloroquine The global database on antimalarial drug efficacy and resistance was initiated in 2000 to centralize data and facilitate reporting on the status of antimalarial drug efficacy in malaria endemic countries. Chloroquine resistance was first reported in both South America and South East Asia in late 1950s. Since then chloroquine resistant strains have spread throughout the ranges where the conditions are favorable for the development of the parasite especially in the regions of sub-Saharan Africa 6. False chloroquine resistance in Africa. Chloroquine is still the drug of choice for the treatment of uncomplicated falciparum malaria in most of sub-Saharan Africa. But the increasing number of therapeutic failures with chloroquine has led to concern about whether this drug can remain effective for long in Africa. This risk estimate is based largely on cases occurring in US military personnel who travel for extended periods of time with unique itineraries that likely do not reflect the risk for the average US traveler.6. All travelers should seek medical attention in the event of fever during or after return from travel to areas with malaria.5. Chloroquine-resistance countries The Origins of Antimalarial-Drug Resistance NEJM, Chloroquine Resistance in Plasmodium falciparum - microbewiki Who makes hydroxychloroquineGlaucoma and plaquenilChloroquine fluoroquinolonesPlaquenil usesPhototherapy and plaquenil combination Chloroquine resistance Chloroquine is ineffective in almost all malaria endemic countries In India chloroquine resistance was first detected in 1973 in Assam. Severe in northeast and southeastern regions of India with high morbidity and mortality. DRUG RESISTANT MALARIA CURRENT STATUS. False chloroquine resistance in Africa - The Lancet. WHO Responding to antimalarial drug resistance. The epicentres of chloroquine-resistance are the eastern provinces of Indonesia, although reports of reduced susceptibility are apparent across the archipelago. Till date, drug resistance has been documented in P. falciparum, P. vivax, and P. malariae. 1 P. falciparum has developed resistance to nearly all antimalarial. In Uganda, chloroquine resistance appears fixed in the population, with the prevalence of purely resistant infections at nearly 100% over a ten-year period. Chloroquine resistance in Burkina Faso increased slightly, with predicted purely resistant infection prevalence ranging from approximately 50-70%.