Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Is hydroxychloroquine a biologic drug Hydroxychloroquine sulfate tablets usp 200 mg side effects Chloroquine brand Chloroquine diphosphate salt storage I take Plaquenil for MCTD and it really helps my joint pain but it doesn't do anything for the more scleroderma - like features like Raynauds and GI issues, and It will not help Scleroderma lung problems. Localized scleroderma is a rare autoimmune disease with primary affection of the skin, and occasional involvement of the fat tissue, muscle, fascia, and bone. Depending on the clinical subtype, the spectrum of skin lesions ranges from singular plaque lesions to severe generalized or linear subtypes. which may lead to movement restrictions and. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Scleroderma plaquenil Scleroderma Skin Involvement Itching Pruritus, Morphea Localized Scleroderma - Dermatology Advisor Plaquenil and ttpPlaquenil for oaMalarone and plaquenilSickle cell disease guidelines hydroxychloroquinePlaquenil chpl Other symptoms. Other symptoms can include dry eyes and mouth, sudden episodes of severe facial pain trigeminal neuralgia, and impotence. More than 95% of people with scleroderma have both Raynaud's phenomenon and skin thickening also called sclerodactyly when the fingers are involved. Scleroderma Guide Causes, Symptoms and Treatment Options. Hydroxychloroquine Plaquenil. Anti-Malarial Medications - Scleroderma News. This is a reivew of how effective Plaquenil hydroxychloroquine sulfate is for Systemic sclerosis scleroderma and for what kind of people. The study is created by eHealthMe from 11 Plaquenil users and is updated continuously. Scleroderma sklair-oh-DUR-muh is a group of rare diseases that involve the hardening and tightening of the skin and connective tissues. Scleroderma affects women more often than men and most commonly occurs between the ages of 30 and 50. While there is no cure for scleroderma, a variety of treatments can ease symptoms and improve quality of life. Hi Maddy, My rheumatologist does consider Plaquenil to be a disease modifying drug. They truly don't know exactly how it works. It does reduce the pain and fatigue and has the ability to "stop the disease in its track and keep it from progressing" Those are my rheumatologist's exact words.