Our team periodically reviews articles in order to ensure content quality. The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data. Nursing interventions prior to plaquenil administration Chloroquine dose Check with your doctor as soon as possible if any of the following side effects occur blurred vision or any change in vision – this effect may also occur or worsen after stopping the medication. change in colour of hair or skin pigment. flu-like symptoms sudden lack of energy, fever, cough, sore throat RARE side effects. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Please check with the appropriate physician regarding health questions and concerns. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Can plaquenil cause acne Healthboards - Immune & Autoimmune - Lupus Strange lupus acne, Common and Rare Side Effects for Plaquenil Oral Plaquenil toxicity icd9Chloroquine and itchingPlaquenil weight gain or loss Warning. Oral route Solution Severe Toxic Reactions, Including Embryo-Fetal ToxicityMethotrexate can cause severe or fatal toxicities. Monitor closely and modify dose or discontinue for the following toxicities bone marrow suppression, infection, renal, gastrointestinal, hepatic, pulmonary, hypersensitivity and dermatologic. Methotrexate can cause embryo-fetal toxicity and fetal death. Methotrexate Side Effects Common, Severe, Long Term.. Plaquenil Side Effects Common, Severe, Long Term -. Acne and Plaquenil. - HealthBoards. Hydroxychloroquine can cause serious liver or heart problems, especially if you use certain medicines at the same time, including other medicines to treat malaria; an antibiotic or antifungal. On Jun, 12, 2013 13,441 people reported to have side effects when taking Plaquenil. Among them, 15 people 0.11% have Cystic Acne. So I'm thinking it's not a side effect of the Plaq, and your doctor is mistaken when she said it was a not uncommon side effect. If it happens in larger blood vessels, it can cause a painful rash, often on the legs. In serious cases, ulcers can form and there’s a chance they could become infected.