I've been taking it for about 6 months now, and I can't tell that it's done a thing. I think I may be overmedicated and was thinking about dropping the plaquenil if there was no benefit to it. Thanks, Elcamino Hi Elcamino, I have been taking Plaquenil (400 mg per day) for about 2 years now due to lupus flare. Hydroxychloroquine sulphate uses Mefloquine and chloroquine wiki Chloroquine phosphate mechanism of action Color dx test results in plaquenil toxicity Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil is supposed to stay in your system for 1-2 months after you stop taking it. Try to rest, stay hydrated and away from sick ppl for now and hopefully you will not have any issues. ranin02. August 26, 2016, am #3. I stopped it during my pregnancies. There is no taper needed or withdrawal, but if it has been helping you, you may have. Dr. S recommended that I stay on Plaquenil and prednisone until I was feeling better too. I really didn't think 1 mg of pred and 250 mg of Plaquenil was doing much for me because I was always in pain. When I backed off of it I really can't say whether I herxed more or that those two meds were actually suppressing some of the pain afterall. Actually I started on 200 mg per day and about 2 months before tapering off pred, he upped me to 400 mg per day of plaquenil to give it plenty of time to kick in. When i first started it, I was also started on prednisone to get my inflammation under control. How long can you stay on plaquenil Lupus remission Lupus Foundation of America, Stopping Plaquenil - General Discussion - Life With Lupus Plaquenil for ulcerative colitisProphylaxis for malaria in chloroquine resistant areaChloroquine phosphate child's dosage malaria prophylaxis If you feel like your central vision is getting blurred, if you lose the ability to see a digital clock, if you lose color vision—if reds look kind of washed out—or if you have trouble seeing at night Those are early signs that you might be developing Plaquenil retinopathy,” says Katz. Protecting your eyesight when taking Plaquenil Lupus Foundation of.. Plaquenil - Road Back Foundation. PLAQUENIL Side Effects, Reviews by Patients -. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Safety of Long term use of Hydroxychloroquine Therapy Further Verified for People with Lupus Hydroxychloroquine Plaquenil® was approved by the Food and Drug Administration for symptoms of lupus. The greatest concern people with lupus have when taking hydroxychloroquine is related to vision and an increase in risk for retinal damage. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.