Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Is diarrhea a side effect of hydroxychloroquine Severe itching plaquenil What does the drug plaquenil do Can plaquenil cause gingivitis in humans Binding of the drug to melanin in the RPE contributes to, or prolongs, its toxic effects. 2. Plaquenil toxicity is typically asymptomatic in early stages, but over time can lead to severe vision loss and retinal damage. An amount of 600 mg of hydroxychloroquine brand name Plaquenil was administered to these patients every day for 10 days. They reported "a significant decrease in viral load". The drug appeared to be responsible for a "rapid and effective speeding up of their healing process, and a sharp decrease in the amount of time they remained contagious". However, because this drug can be safely prescribed to infants, the effects are not harmful. Studies with mice show that radioactively tagged chloroquine passed through the placenta rapidly and accumulated in the fetal eyes which remained present five months after the drug was cleared from the rest of the body. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Drug metabolism of plaquenil Plaquenil Concordia Pharmaceuticals Inc. FDA Package Insert, Hydroxychloroquine - Wikipedia Plaquenil 200mg buy WebMD provides information about interactions between Plaquenil Oral and selected-cyp2d6-inhibitors-metoprolol. Hinz B, Brune K. Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate. Interactions between Plaquenil Oral and selected-cyp2d6.. Chloroquine - Wikipedia. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Drug interactions are reported among people who take Propofol and Plaquenil together. This study is created by eHealthMe based on reports of 23 people who take Propofol and Plaquenil from Food and Drug Administration FDA, and is updated regularly. On eHealthMe, you can evaluate side effects and drug interactions from 16 million FDA reports. Oct 22, 2019 The risk may also be higher with some doses of Plaquenil hydroxychloroquine, if you use Plaquenil hydroxychloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Call your doctor right away if you have any eyesight changes like blurred or foggy eyesight, trouble focusing or reading, or trouble seeing in dim light. The mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Studies have shown that the drug affects the metabolism of retinal cells and also binds to melanin in the RPE, which could explain the persistent toxicity after discontinuation of the medication.