The fever is usually above 39 °C (102 °F) and sometimes reaching 40 °C (104 °F) and may be biphasic—lasting several days, breaking, and then returning. Fever occurs with the onset of viremia, and the level of virus in the blood correlates with the intensity of symptoms in the acute phase. Hydroxychloroquine dosage for malaria prevention Chloroquine phosphate mechanism of action Chloroquine, which is commonly used to treat febrile illnesses in the tropics, has been shown to inhibit CHIKV replication in vitro. To assess the in vivo effect of chloroquine, two complementary studies were performed i a prophylactic study in a non-human primate model NHP; and ii a curative study "CuraChik", which was performed during. Due to the alkalisation of endosomes, chloroquine was an effective in vitro treatment against Chikungunya virus when added to Vero cells prior to virus exposure. The mechanism of inhibition likely involved the prevention of endocytosis and/or rapid elevation of the endosomal pH and abrogation of virus–endosome fusion. Chloroquine is also in trials as an antiretroviral for HIV-1/AIDS and is being considered in pre-clinical models as a potential agent against chikungunya and Zika. However, headache, insomnia and an extreme degree of exhaustion remain, usually about five to seven days. When Ig M, an antibody that is a response to the initial exposure to an antigen, appears in the blood, viremia begins to diminish. Chloroquine chikungunya On the use of chloroquine for chikungunya - The Lancet., New insights on the antiviral effects of chloroquine. Hydroxychloroquine for raHydroxychloroquine skin darkeningPlaquenil sulfate allergyChloroquine diphosphate salt autophagy Chikungunya virus, a re-emerging mosquito-borne alphavirus, causes fever, rash and persistent arthralgia/arthritis in humans. Severe outbreaks have occurred resulting in infections of millions of people in Southeast Asia and Africa. Currently there are no antiviral drugs or vaccines for prevention and treatment of chikungunya infections. Approaches to the treatment of disease induced by chikungunya.. Anti-malaria drug being tested for efficacy against COVID-19. PDF Paradoxical Effect of Chloroquine Treatment in.. Chloroquine is gaining ground as a possible treatment for the symptoms associated with chikungunya, and as an anti-inflammatory agent to combat the arthritis associated with chikungunya virus. Efﬁcacy of Chloroquine Against Chikungunya Virus in Vero Cells Mohsin Khan, S. R. Santhosh, Mugdha Tiwari, P. V. Lakshmana Rao, and Manmohan Parida* Division of Virology, Defence Research & Development Establishment DRDE, Gwalior, MP, India The resurgence of Chikungunya virus CHIKV in the form of unprecedented and explosive epi- Many articles don't mention chloroquine at all. A few articles strongly recommend this Zhi 2020, Gao 2020 Chikungunya Virus Caveat Chloroquine was effective for chikungunya virus in vitro, but subsequently failed to work in primate model in fact, immunosuppressive effects of chloroquine actually increased viral levelsRoques et al 2018.