Hydroxychloroquine-induced pigmentation

Discussion in 'Hydroxychloroquine 200mg' started by NoMa, 10-Mar-2020.

  1. VirLad Moderator

    Hydroxychloroquine-induced pigmentation


    In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent.

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    The few reports of bluish pigmentation with HCQ described resolution within a few months or did not specifiy the duration of pigmentation after discontinuation of the drug 4, 5, 6. Hydroxychloroquine is converted to an inactive metabolite in the liver and excreted in urine 25% in the active form and bile. Skin figure 1A,B. There was no pigmentation at other body sites. Biopsy from the plaque showed necrobiotic collagen with intradermal mucin and perivascular lymphohistiocytic infiltrate accom-panied by brown coarse pigment in the dermis figure 1C,D. The pigment was negative on Perl’s stain figure 1E. This was a unique pattern of Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ.

    Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended.

    Hydroxychloroquine-induced pigmentation

    Hydroxychloroquine-induced hyperpigmentation in systemic., Hydroxychloroquine induced cutaneous pigmentation a unique pattern

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  4. Conclusions HCQ-induced pigmentation is considered uncommon adverse effect of HCQ, with a prevalence rate of 49.2% indicated in this study. Furthermore, history of bruising, sun exposure, and the presence of mucous membrane pigmentation are possible predisposing factors.

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    Hydroxychloroquine-Induced Hyperpigmentation. From the Departments of *Rheumatology and †Dermatology, Walter Reed National Military Medical Center; and ‡Uniformed Services University of the Health Sciences, Bethesda, MD. No financial support was received for this study. The authors declare no conflict of interest. The imputability of hydroxychloroquine in the genesis of this discoloration is difficult to establish. Our study supports the hypothesis that ecchymosis, platelet antiaggregants and oral anticoagulants may be the main predisposing factors to hydroxychloroquine-induced pigmentation. HCQ is often prescribed for longer durations and may be associated with cutaneous adverse effects such as yellow-brown or slate-grey pigmentation, bleaching of hair, exacerbation of pre-existing psoriasis, cutaneous rashes and pruritus. 1 Cutaneous pigmentation occurs in 10%–30% patients, most commonly over shins.

     
  5. NikMc User

    Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. Compare Plaquenil vs Prednisolone - Comprehensive Analysis by Treato PATIENT FACT SHEET Hydroxychloroquine Plaquenil Prednisone and Plaquenil drug interactions - eHealthMe
     
  6. cruises XenForo Moderator

    Chloroquine Oral Uses, Side Effects, Interactions. Chloroquine belongs to a class of drugs known as antimalarials. The United States Centers for Disease Control provide updated guidelines and travel recommendations for the prevention and treatment.

    CHLOROQUINE PHOSPHATE, USP
     
  7. tyron Guest

    Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. diarrhea, dizziness, or headache.

    Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center