Your back might be telling you to avoid a certain activity, or it could be warning of a more serious underlying issue in your spine. The first step to understanding what your back muscle spasm is telling you is to visit a doctor and get an accurate diagnosis. Chloroquine malarone Can plaquenil cause a rash Apr 28, 2009 My knees and legs hurt, back, hips, shoulders, fingers, and now my left heel - which has me limping half the time. I felt the Plaquenil helped the fatigue, but it seems the pain is sabotaging that effect. It also stopped my hair loss and soon after starting it, the skin on my face became more normal and less coarse. I was thrilled. Commonly, muscle spasms are normal responses to muscle overexertion, pain, or fatigue. However, in some circumstances, they imply serious systemic or neurological disease. It is important to understand the timing, frequency, duration, pattern, and overall setting in which muscles spasms occur. I have some sort of auto immune issue with lots of joint pain and fatigue. I have been on plaquenil for about 10 weeks now without much success. My doctor said if I don't feel better in a few more weeks, we could switch my medicine. He said it would be one that they would have to more closely monitor me on with some blood tests. It is important to seek medical attention to treat the underlying cause of your symptoms, rather than just treating the symptoms. In general, most back muscle spasms occur because of the following reasons: When these or other underlying anatomical problems are present in the spine, muscle spasms are likely to keep recurring due to ongoing inflammation or instability. Stopped my plaquenil now having muscle spasms Leading Causes Of Muscle Twitches And Spasms - HealthPrep, Muscle Spasms - Plaquenil retina toxicity Jun 25, 2013 Call your doctor at once if you have a serious side effect such as muscle weakness, twitching, or uncontrolled movement; loss of balance or coordination; blurred vision, light sensitivity, seeing halos around lights; pale skin, easy bruising or bleeding; confusion, unusual thoughts or behavior; or seizure convulsions. Hydroxychloroquine - thigh muscle weakness?. What next if plaquenil doesn't work?. Will you have Muscle spasms with Plaquenil - eHealthMe. Hydroxychloroquine plaquenil withdrawl. I'd forgotten how bad they were before I was on it. Does anyone know if plaquenil would have stopped headache symptoms? I just wasn't sure if it would have helped with them anyway. My sister is now experiencing more pain similar to mine. I think she has Fibro too on top of Lupus & RA. One of the problems with Plaquenil is that because it's so slow to act, the improvements are also slow and subtle. So most people don't realize that they've improved until they STOP taking it. I've been on it twice, along with Atabrine another antimalarial. In my case, it never worked so I didn't notice a change. But occasionally the cramping is so severe that you may have sore muscles after for a day or so.". Although you can’t diagnose a problem based on just muscle spasms and severe discomfort, Danesh says that it could be a sign of something like an inadequate blood supply getting to your limbs.