It typically happens in the evening or nighttime hours when you're sitting or lying down. Restless legs syndrome, also known as Willis-Ekbom disease, can begin at any age and generally worsens as you age. It can disrupt sleep, which interferes with daily activities. What does plaquenil do for sjogrens Can plaquenil cause cancer Plaquenil and tinazidole Hydroxychloroquine 200 mg discounts You might feel stiffness the most when you first get up after time spent sitting — as when driving in the car — or after a night of sleep. If stiffness is chronic or gets worse with time, see a doctor to rule out arthritis or another medical condition. Otherwise, use simple stretches, water therapy and other movement to relieve your stiff legs. Muscles stiffness can also be accompanied by pain, cramping, and discomfort. It is usually not a cause for concern and can be treated with home remedies and stretching. I have mild Lupus with no organ involvement. ANA+. For well over a year I have been experiencing ongoing, unrelenting muscle spasms and stiff, sore legs from the spasms which seem to happen most often in my lower body. Medications also help many people with symptoms as abnormal, unpleasant sensations in their legs or feet. They do, however, consistently describe the desire to move their legs. Sometimes, symptoms disappear for periods of time, then come back. Simple self-care steps and lifestyle changes may help relieve symptoms. The sensations, which generally occur within the limb rather than on the skin, are described as: usually don't describe the condition as a muscle cramp or numbness. Does plaquenil caus stiff legs Plaquenil and muscle aches and pains?, Muscle stiffness Causes, symptoms, and treatment Chloroquine rheumatoid arthritis mechanism of actionHydroxychloroquine pancreatitisChloroquine phosphate flukesDoes plaquenil cause eye problems Stiff, sore muscles might be a sign that your daily diet is missing key nutrients. Your body requires at least 2.4 micrograms of vitamin B-12 every day; sources include meat, milk and dairy products. This vitamin plays a critical role in producing healthy red blood cells that carry oxygen and nutrients to your muscles and tissues. Nutritional Cause of Stiff Leg Muscles Healthfully. Muscle Spasms, Stiff Legs - Lupus - MedHelp. Burning Feet Syndrome Grierson-Gopalan Syndrome. VICKABB responded I don't know for sure if it is the plaquenil or other meds but my rheumy seems to have my inflammation/stiffness under pretty good control. Been taking plaquenil and arava for about a year. Just rediced plaquenil from one tablet twice a day to one tablet once a day. Hi, although Plaquenil is prescribed for autoimmune diseases, such as yours, it can actually add to/increase the number of the symptoms. Muscle damage and leg pain being just 2 examples. It is great that you have responded so well to the new medication. I have been on Plaquenil for years. It has not helped me with fatigue. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness.