Although their therapeutic and toxic doses differ, they are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity. The image below depicts hydroxychloroquine retinopathy. Fluorescein angiogram of left macula in patient with hydroxychloroquine retinopathy. Does plaquenil interact with gerd Patient teaching for hydroxychloroquine How to take hydroxychloroquine Aug 29, 2014 Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases. Researchers suggest that one central point in both eyes indicates toxicity and one should have a low threshold with regards to any defects. 19 The misinterpreted visual field defect using the larger testing strategies could potentially delay the diagnosis of Plaquenil toxicity resulting in irreversible vision loss. Due to the possibility of. But I was wondering if you don't mind what your dosage/frequency and your weight was when taking Plaquenil? I ask because I may be starting soon on Plaquenil and am afraid of toxicity. I have read that when you figure up the dosage of Plaquenil, that you want to go by your lean weight and not your actual weight. As they say Plaquenil doesn't. Retinopathy may be asymptomatic or may cause central or paracentral scotomas leading to difficulty reading or performing fine visual tasks (due to parafoveal metamorphopsia). Reprinted from American Journal of Ophthalmology, Vol 104, Johnson and Vine, Hydroxychloroquine therapy in massive total doses without retinal toxicity, pages 139-144, Copyright 1987, with permission from Elsevier Science. Color dx test results in plaquenil toxicity A New Objective Parameter in Hydroxychloroquine-Induced., How to Succeed in Plaquenil Screenings Chloroquine function in lysosomePlaquenil toxicity eye examPlaquenil and tb The Risk of Retinal Toxicity with Plaquenil. The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. The Risk of Retinal Toxicity with Plaquenil - Sjogren's. Eye exam / Plaquenil -. Detection of Early Hydroxychloroquine Retinal Toxicity.. Other tests that are not part of the routine Edmonton hydroxychloroquine testing protocol Fluorescein angiography If damage from hydroxychloroquine is suspected, an ophthalmologist may order this test to help confirm the diagnosis. This test involves injecting dye into the arm followed by photographs of the back of the eye. The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. A 53-year-old female with a complaint of something "funny" with her vision. The possibility of hydroxychloroquine toxicity was entertained, although clinical evidence was not found. Color vision testing and funduscopic examination were normal. A full field electroretinogram was normal, but foveal cone electroretinograms were reduced bilaterally.