The methods of quantification of HCQ sulfate, despite the undeniable advantages, have certain limitations, such as high cost of operation and maintenance of equipment, sample processing and analysis of the results relatively complicated. However, the simplicity of the process and velocity of the spectrophotometry by absorption in the UV -Vis region corroborate the usefulness of this methodology. Hydroxychloroquine retinopathy pathogenesis Taking plaquenil and hands still swollen Chloroquine 250 mg tab Visual field test for hydroxychloroquine Identification and Characterization of Process Related Impurities in Chloroquine and Hydroxychloroquine by LC/IT/MS, LC/TOF/MS and NMR Retinal toxicity Retinal toxicity, potentially causing irreversible retinopathy, is predominantly associated with high daily doses and a duration of 5 years of use of chloroquine or hydroxychloroquine in the treatment of rheumatic diseases. Dongre VG, Ghugare PD, Karmuse P, Singh D, Jadhav A and Kumar A Identification and characterization of process related impurities in chloroquine and hydroxychloroquine by LC/IT/MS, LC/TOF/MS and NMR. Journal of Pharmaceutical and Biomedical Analysis 2009; 49 873-79. The method was developed from the sample preparation used in the determination of HCQ in dosage form according to the methodology described by the USP 36. This work describes the application of Qb D in the development, optimization, and validation of an analytical method by absorption spectrophotometry in the UV-Vis region for quantification of HCQ sulfate. Process related impurities in chloroquine and hydroxychloroquine Hydroxychloroquine and Impurities, Anti-Infectives., Hydroxychloroquine Professional Patient Advice - Hydroxychloroquine cause rashChloroquine primaquinePlaquenil pre maculopathy The focus of this study is identification and characterization of major unknown impurities in chloroquine CQ and hydroxychloroquine HCQ bulk drug samples using liquid chromatography/ion trap mass spectrometry LC/IT/MS and liquid PDF Identification and characterization of process related.. International Journal Of -. Hydroxychloroquine - SynZeal. Chloroquine CQ Fig. 1A is the first-choice drug to treat cases of non-complicated malaria caused by P. vivax 3. Due to the inappropriate use of CQ, there are reports of P. vivax resistance to this drug in some countries of Africa and South America 4. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of. The latter is related to drug accumulation in melanin-rich tissues. 15,16 Prolonged treatment with chloroquine also can cause toxic myopathy, cardiopathy, and peripheral neuropathy and neuropsychiatric disturbances; all of these reactions improve if the drug is discontinued promptly. 17,18 Both chloroquine and hydroxychloroquine should be used.