Process related impurities in chloroquine and hydroxychloroquine

Discussion in 'Hydroxychloroquine' started by boususessyNok, 18-Mar-2020.

  1. dr_Min Moderator

    Process related impurities in chloroquine and hydroxychloroquine

    The methods of quantification of HCQ sulfate, despite the undeniable advantages, have certain limitations, such as high cost of operation and maintenance of equipment, sample processing and analysis of the results relatively complicated. However, the simplicity of the process and velocity of the spectrophotometry by absorption in the UV -Vis region corroborate the usefulness of this methodology.

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    Identification and Characterization of Process Related Impurities in Chloroquine and Hydroxychloroquine by LC/IT/MS, LC/TOF/MS and NMR Retinal toxicity Retinal toxicity, potentially causing irreversible retinopathy, is predominantly associated with high daily doses and a duration of 5 years of use of chloroquine or hydroxychloroquine in the treatment of rheumatic diseases. Dongre VG, Ghugare PD, Karmuse P, Singh D, Jadhav A and Kumar A Identification and characterization of process related impurities in chloroquine and hydroxychloroquine by LC/IT/MS, LC/TOF/MS and NMR. Journal of Pharmaceutical and Biomedical Analysis 2009; 49 873-79.

    The method was developed from the sample preparation used in the determination of HCQ in dosage form according to the methodology described by the USP 36. This work describes the application of Qb D in the development, optimization, and validation of an analytical method by absorption spectrophotometry in the UV-Vis region for quantification of HCQ sulfate.

    Process related impurities in chloroquine and hydroxychloroquine

    Hydroxychloroquine and Impurities, Anti-Infectives., Hydroxychloroquine Professional Patient Advice -

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  5. The focus of this study is identification and characterization of major unknown impurities in chloroquine CQ and hydroxychloroquine HCQ bulk drug samples using liquid chromatography/ion trap mass spectrometry LC/IT/MS and liquid

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    • Hydroxychloroquine - SynZeal.

    Chloroquine CQ Fig. 1A is the first-choice drug to treat cases of non-complicated malaria caused by P. vivax 3. Due to the inappropriate use of CQ, there are reports of P. vivax resistance to this drug in some countries of Africa and South America 4. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of. The latter is related to drug accumulation in melanin-rich tissues. 15,16 Prolonged treatment with chloroquine also can cause toxic myopathy, cardiopathy, and peripheral neuropathy and neuropsychiatric disturbances; all of these reactions improve if the drug is discontinued promptly. 17,18 Both chloroquine and hydroxychloroquine should be used.

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    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Hydroxychloroquine Side-effects, uses, time to work HSDD Hydroxychloroquine Dosage Guide with Precautions -
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    Chloroquine Side Effects Common, Severe, Long Term - Jul 30, 2019 On day 3 of chloroquine therapy, she developed localized brisk bullous eruptions in the irradiated area, which developed into a patch of fulminant moist desquamation. After radiotherapy was withheld for 1 week, the moist desquamation had almost healed.

    Chloroquine - The Underground