Hydroxychloroquine and chloroquine assessing the risk of retinal toxicity

Discussion in 'Northwest Pharmacy Canada' started by Lem, 03-Mar-2020.

  1. Ephettekenpal New Member

    Hydroxychloroquine and chloroquine assessing the risk of retinal toxicity


    In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio.

    Cellcept and plaquenil Chloroquine in liver Chloroquine toxicity eye

    Objective To report the detailed clinical findings of patients with retinal toxicity that developed secondary to the use of hydroxychloroquine sulfate n = 13, chloroquine phosphate n = 2, or a combination of the agents n = 1. Methods Ophthalmologic examination, fundus photography, visual field testing, and detailed electrophysiologic assessment were undertaken in all 16 affected patients. In particular, chloroquine and hydroxychloroquine Plaquenil are two such medications, with the potential for retinal toxicity. Given that the retinal damage from these medications is largely irreversible, screening by a retinal specialist is critical to detect early retinal toxicity to try and limit the extent of visual loss. Nov 01, 2015 H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible.

    As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits.

    Hydroxychloroquine and chloroquine assessing the risk of retinal toxicity

    Hydroxchloroquine and Chloroquine Toxicity, Retinal Screening for Hydroxychloroquine Plaquenil Toxicity

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  6. Daily hydroxychloroquine base doses 5 mg/kg actual body weight were associated with an ~10% risk of retinal toxicity within 10 years of treatment and an almost 40% risk after 20 years of therapy. Risk is most accurately assessed on the basis of duration of use relative to daily dose/body weight Marmor AAO 2016; Melles 2014.

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    Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ. Commonly used on holidays in malaria prone destinations, chloroquine and hydroxychloroquine will not be over familiar to the emergency physician. However, it is one of the leading causes of drug overdose in malaria prone countries and also the occasional toddler has managed to consume the grandparents lupus or rheumatoid arthritis medication leading to lethal consequences. When allowed to advance, hydroxychloroquine retinal toxicity leads to loss of up to three visual functions acuity, peripheral vision and night vision. Signs. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye.

     
  7. NovikL Well-Known Member

    Suppression: 400 mg (310 mg base) orally on the same day every week Comments: -Suppressive therapy should begin 2 weeks prior to exposure; however, failing this, an initial dose of 800 mg (620 mg base) may be taken in 2 divided doses (6 hours apart). Plaquenil Hydroxychloroquine for Lupus - LupusCorner Efficacy and Safety of Hydroxychloroquine for Treatment of. Treatment of hydroxychloroquine overdose - ScienceDirect
     
  8. seonewbie Well-Known Member

    Chloroquine Phosphate REEF2REEF Saltwater and Reef Aquarium. Feb 22, 2019 Day 17 Chloroquine Phosphate CP. CP is a white powder chemical that is used in a class of drugs called antimalarials and amebicides. It is used to prevent and treat malaria. It is also used to treat amebiasis. The most common dosage for CP is 40mg/Gal. Mix the dose according to your tank size and let it do its job for 30 days.

    Chloroquine phosphate dosing REEF2REEF Saltwater and.
     
  9. Aralen Chloroquine Uses, Dosage, Side Effects. The dosage of chloroquine phosphate is often expressed in terms of equivalent chloroquine base. Each 500 mg tablet of ARALEN contains the equivalent of 300 mg chloroquine base. In infants and children the dosage is preferably calculated by body weight. Malaria. Suppression — Adult Dose 500 mg = 300 mg base on exactly the same day of each week.

    Chloroquine Dosage Guide with Precautions -