Psoriatic arthritis is a combination of both skin and arthritic symptoms, but the inflammation that drives the condition makes symptom management difficult. Learn more about the effects of psoriatic arthritis on the body, as well as symptoms to watch for. Does plaquenil suppress the immune system Hydroxychloroquine skin discoloration Plaquenil food interactions Some people who have psoriatic arthritis also have fibromyalgia, which causes muscle pain, joint stiffness, and fatigue. The psoriasis rash may appear before or after arthritis develops. Sometimes the rash is not noticed because it is hidden in the scalp, navel, or creases of the skin such as between the back of the buttocks and thigh. Find information about common, infrequent and rare side effects of Plaquenil Oral. Medical usesHistorySide effectsMechanism of actionResultsAdministrationRisksDiagnosisInteractionsPreventionBenefits In some cases, it’s diagnosed before you have skin psoriasis because the symptoms might be more noticeable. According to the National Psoriasis Foundation, about 30 percent of people with psoriasis eventually develop Ps A. Plaquenil causes leg weakness in psoriatic arthritis Psoriatic Arthritis Muscle Weakness -, Common and Rare Side Effects for Plaquenil Oral Chloroquine phosphate where to buyHydroxychloroquine contraindicated in pregnancyPlaquenil reduction This drug works by suppressing the immune system, which is why it has so many and serious side effects. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. Why does Plaquenil cause severe flares in people with.. Taking Plaquenil for Rheumatoid Arthritis. Effects of Psoriatic Arthritis on the Body. Here are 10 symptoms of psoriatic arthritis, a chronic condition in which the immune system attacks the body, causing joint pain and other symptoms. Plaquenil is a prescription medication approved by the Food and Drug Administration FDA in 1955. Plaquenil is sometimes prescribed to treat inflammation in people with psoriatic arthritis. Plaquenil is also known by its drug name, Hydroxychloroquine. Psoriatic arthritis is a form of arthritis that typically occurs in people with psoriasis. In addition to pain, stiffness, and swelling of the joints, psoriatic arthritis can cause a red, scaly rash.