Controlled studies in pregnant women show no evidence of fetal risk. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. Animal studies show risk and human studies not available or neither animal nor human studies done. Contact the applicable plan provider for the most current information. D: Use in LIFE-THREATENING emergencies when no safer drug available. Plaquenil eye exam coding Plaquenil forlimited sclera derma Eye things behind eye from taking plaquenil When chloroquine, doxycycline, or mefloquine is used for primary prophylaxis, primaquine is usually taken during the last 2 weeks of postexposure prophylaxis. When atovaquone-proguanil is used for prophylaxis, primaquine may be taken during the final 7 days of atovaquone-proguanil, and then for an additional 7 days. The standard chloroquine dose for treating malaria in adults is a one-time loading dose of 1000 mg, followed by 500 mg in six to eight hours. Then 500 mg is taken once a day for two more days. The standard dosage for malaria treatment in children is based on the child's weight. The pharmacokinetics of chloroquine were studied in healthy volunteers who received one of three different multiple-dose regimens for 3 weeks once weekly 300 mg, twice weekly 200 mg and once daily 50 mg chloroquine. Plasma concentrations of chloroquine and metabolites were determined by h.p.l.c. with fluorescence detection. Active against erythrocytic forms of Plasmodium vivax & P. malariae and most strains of Plasmodium falciparum Precise mechanism not known Bioavailability: ~89% Peak plasma time: 1-2 hr Distributed widely in body tissues (eg, eyes, heart, kidneys, liver, lungs) where retention prolonged; crosses placenta; enters breast milk Partially in liver Half-life: 3-5 days Excretion: urine (~70% as unchanged drug); acidification of urine increases elimination Small amounts may be present in urine months following discontinuation of therapy The above information is provided for general informational and educational purposes only. Chloroquine for malaria prophylaxis dosing Chloroquine - FDA prescribing information, side effects and uses, Chloroquine Dosage - Malaria Home Page Delayed pressure urticaria hydroxychloroquineCornea verticillata plaquenil Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments -If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate. Chloroquine Dosage Guide with Precautions -. The pharmacokinetics of three multiple dose regimens of.. Chloroquine Phosphate chloroquine phosphate dose.. Infections should receive chloroquine prophylaxis 300 mg base po once a week during pregnancy. After delivery, patients with normal G6PD activity should be treated with primaquine or tafenoquine or continue with chloroquine prophylaxis for a total of 1 year. Primaquine can be used during breastfeeding if the infant is found Aug 04, 2007 Chloroquine and proguanil, used alone or together, are the most commonly utilised drugs in prophylaxis against malaria. It is advised that prophylaxis must start 1 week before travel into an endemic area and should be continued for 4 weeks after return. The recommended dose of chloroquine for an adult is 300 mg once weekly and proguanil 200 mg. Irreversible retinal damage observed in some patients; significant risk factors for retinal damage include daily doses of chloroquine phosphate 2.3 mg/kg of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate, and concurrent macular disease.