Falciparum resistance is reported, especially in persons likely to have acquired a significant degree of immunity, and also wherever P. Chloroquine is a 4-aminoquinoline which has marked, rapid schizontocidal activity against blood forms of P. Adults, including pregnant women, and children: Total dose: 25 mg/kg given over 3 days. Treatment Oral administration To avoid nausea and vomiting chloroquine should be administered after meals. Difference between chloroquine and quinine Hydroxychloroquine overdose toxicokinetics and management Adults 250 mg P. O. daily chloroquine phosphate with evening meal. Lupus erythematosus. Adults 250 mg P. O. daily chloroquine phosphate with evening meal; reduce dosage gradually over several months when lesions regress. Pharmacodynamics Antimalarial action Chloroquine binds to DNA, interfering with protein synthesis. It also inhibits DNA and RNA polymerases. The excretion of chloroquine and the major metabolite, desethylchloroquine, in breast milk was investigated in 11 lactating mothers following a single oral dose of chloroquine 600 mg basemaximum daily dose of the drug that the infant received from breast-feeding was about 0.7% of the maternal start dose of the drug in malaria chemotherapy. Chloroquine is an antimalarial medication which is used in the treatment as well as prophylaxis of malaria. This medicine is not recommended in patients with the eye disease. Liver function and blood cell count monitoring is necessary while receiving this medicine. Know Chloroquine uses, side effects, dosage, contraindications, benefit, interactions, purpose, drug interactions, precautions. Chloroquine is also used for prophylaxis for pregnant women and non-immune individuals at risk. Dosage and administration All dosages are described in terms of the base. Chloroquine injection dosage Chloroquine Oral Uses, Side Effects, Interactions., Chloroquine Phosphate chloroquine phosphate dose. Chloroquine regimenPatient assistance program for plaquenil Nov 25, 2019 To treat malaria Chloroquine is usually given for 3 days, starting with one high dose followed by a smaller dose during the next 2 days in a row. To treat amebiasis Chloroquine is given in a high starting dose for 2 days followed by a smaller dose for 2 to 3 weeks. You may be given other medications to help prevent further infection. Chloroquine Uses, Side Effects & Warnings -. Chloroquine - Uses, Dosage, Side Effects, Composition & more.. Chloroquine Indications, Side Effects, Warnings -. This represents a total dose of 2.5 g chloroquine phosphate or 1.5 g base in three days. The dosage for adults of low body weight and for infants and children should be determined as follows First dose 10 mg base per kg but not exceeding a single dose of 600 mg base. The dosage of Chloroquine phosphate is often expressed in terms of equivalent Chloroquine base. Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg Chloroquine base. In infants and children the dosage is preferably calculated by body weight. The dose for treating children is 10 mg/kg for the first dose then 5 mg/kg daily for 2 days, starting 6 hours after the first dose. The dose for treating intestinal amebiasis is 1 g daily for two days, followed by 500 mg daily for at least two to three weeks. Chloroquine usually is combined with an effective intestinal amebicide.