Existing prophylactic regimens for areas where there is CQ-resistant malaria recommend CQ with proguanil as an alternative where none of the three preferred regimens (atovaquone–proguanil, doxycycline or mefloquine) is thought suitable. In such cases, toxicity is likely when CQ–proguanil is administered to persons being treated for autoimmune disease with daily HCQ. Hydroxychloroquine histamine Hydroxychloroquine med Plaquenil white hair Hydroxychloroquine gh Mefloquine is used as a treatment for chloroquine-sensitive or resistant Plasmodium falciparum malaria, and is deemed a reasonable alternative for uncomplicated chloroquine-resistant Plasmodium vivax malaria. It is one of several drugs recommended by the United States' Centers for Disease Control and Prevention. The 4-aminoquinoline drug hydroxychloroquine HCQ is reported to be as active as chloroquine CQ against falciparum malaria, and less toxic. Mefloquine resistance is felt to come from the exposure of P. falciparum to quinine, and not the exposure of the parasite to mefloquine. Mefloquine and several other anti-malarial meds is an analog of quinine, and quinine is the gold standard for treating complicated malaria. We confirmed similar activity of CQ and HCQ against CQ-sensitive was 1.6 times less active than CQ in a CQ-sensitive isolate, it was 8.8 times less active in a CQ-resistant isolate. The question therefore arises whether in such circumstances HCQ could effectively replace the CQ component of the prophylactic combination. Mefloquine vs chloroquine The antimalarial drugs quinine, chloroquine and mefloquine are., Hydroxychloroquine is much less active than chloroquine. Plaquenil causing hearing lossBob & aralene goldberg foundation Hydroxychloroquine HCQ, is a 4-aminoquinoline drug used widely in autoimmune disease, but has also been employed for the treatment of malaria,1 where it is reported as being half as toxic as the closely-related chloroquine CQ yet equally active against Plasmodium falciparum.2 In UK travel medicine, three drug regimens atovaquone. Hydroxychloroquine is much less active than chloroquine against.. Mefloquine and doxycycline the facts Health - Lonely Planet Forum.. Mefloquine Uses, Side Effects & Warnings -. Jun 15, 2004 In the United States, currently approved prophylaxis options for nonimmune children are chloroquine, proguanil, mefloquine, and atovaquone-proguanil. Resistance to chloroquine among parasites is widespread, and mefloquine has been associated with potentially serious neuropsychiatric side effects 17, 18. Although it has been approved for. Cannot be used in areas with chloroquine or mefloquine resistance; May exacerbate psoriasis; Some people would rather not take a weekly medication; For trips of short duration, some people would rather not take medication for 4 weeks after travel; Not a good choice for last-minute travelers because drug needs to be started 1-2 weeks prior to travel Compare Mefloquine vs. Plaquenil. Head-to-head comparisons of medication uses, side effects, ratings, and more. Treats malaria and autoimmune conditions including rheumatoid arthritis and lupus. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs.