Chewed nails suggest anxiety, buffed nails hint at good grooming, stained nails identify a smoker, blue nails connote oxygen deprivation, and spoon-shaped nails often mean that a patient needs more vitamin B), and a working familiarity with nail “vocabulary” can help pharmacists identify specific nail changes. Drug-induced nail changes can perplex even expert dermatologists, however. Hydroxychloroquine in rheumatoid arthritis mechanism of action Chloroquine astrocytoma Reducing plaquenil dosage Can use of plaquenil have effect on vaccinations years later Nail symptoms explained Signs you shouldn't ignore. What do ridges on nails, white spots mean? Your nails can signal everything from lung conditions to anemia. Thin and brittle nails can be a sign of hypothyroidism, for example. The term onychoschizia refers to splitting of the fingernails as well as brittle or soft nails. Taking biotin a vitamin supplements can help in some cases of brittle nails, and application of moisturizers after soaking in water can also be of benefit. Nonmelanic pigmentation occurs when the nail matrix extracts the drug and stores it in the nail, or the drug deposits in the nail or subungual area. The nail may turn blue, brown, or gray, depending on the drug, and the color will grow out as the nail does. 1,20,21. Irritant or allergic reactions. Drug-induced changes may accumulate in, and discolor, the nail or surrounding skin. Most drug-induced nail changes occur when a drug affects the nail epithelia, but drugs can also affect the nail matrix, the nail bed, or the periungual tissue. Plaquenil brittle nails Brittle Toenails Causes and Treatment Options, Brittle Nails Symptoms, Signs, Causes & Treatment Effect of chloroquine injection on early pregnancyPlaquenil and coughing I was speaking with a friend of mine. Her mother was on plaquenil and had a terrible reaction to it. Rashes and such. Her doctor took her off it, but not befor she lost her toe nails and finger nails! My toe nails have started to discolour and look as if there is a fungal infection. I'm. Plaquenil and toe nails ProHealth Fibromyalgia, ME/CFS.. Drug-Induced Nail Changes Counting to 10. Smelly hands every morning,brittle cracking nails - LUPUS UK. About 1 in 5 of people with rheumatoid arthritis get rheumatoid nodules. These hard lumps of tissue range in size from about the size of a pea to as large as a ping pong ball. They may develop under the skin over bony areas such as the elbow, ankle, or finger. They can also form on organs such as the lungs. Drug-induced nail disease is diagnosed when a medication affects nail growth or structure. Drugs may cause Changes to the shape of the nail nail deformity Changes in the texture or composition of the nail nail dystrophy Abnormality of the tissues around the nail paronychia Pigmentation of the nail plate. Brittle nails tend to split, peel, and break easily. Learn about the causes of brittle nails, treatment options, and ways to prevent them.