Hydroxychloroquine retinopathy mechanism

Discussion in 'Reliable Pharmacy' started by JefriSaUSA, 08-Mar-2020.

  1. nekirill Moderator

    Hydroxychloroquine retinopathy mechanism


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of. Mechanism of Toxicity. The mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Studies have shown that the drug affects the metabolism of retinal cells and also binds to melanin in the RPE, which could explain the persistent toxicity after discontinuation of the medication. Importance Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity bull’s eye maculopathy.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Hydroxychloroquine retinopathy mechanism

    Plaquenil - FDA prescribing information, side effects and uses, Hydroxychloroquine-Induced Retinal Toxicity - American.

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  7. HCQ is widely used for the treatment of rheumatic diseases, particularly lupus and RA. It is generally well tolerated, but retinopathy is a concern. Retinopathy is rare, but is sight threatening, generally irreversible and may progress even after cessation of therapy. Damage may be subclinical.

    • Hydroxychloroquine-related retinal toxicity Rheumatology..
    • Toxic Retinopathy With Hydroxychloroquine Therapy - JAMA.
    • Hydroxychloroquine toxicity - EyeWiki.

    Aug 30, 2011 Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. Dec 04, 2014 Hydroxychloroquine HCQ retinopathy can result in permanent vision loss. In early stages of HCQ retinopathy, patients are usually asymptomatic with preservation of visual acuity. Chloroquine and hydroxychloroquine are drugs with still incompletely understood mechanisms of action, but their ability to alter intracellular pH, suppress CD4+ T-cells activity and promote the activation of CD8+ T-cells makes them useful in an array of disorders of different etiologies 1 2.

     
  8. MaximSh User

    Atovaquone/Proguanil (Malarone) Adults: 1 adult tablet daily. Compare Malarone vs Chloroquine - Atovaquone-Proguanil - Side Effects, Dosage, Interactions. Chloroquine Phosphate Prices, Coupons & Savings Tips - GoodRx
     
  9. vizirn Guest

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  10. . ADS Guest

    Canada Plaquenil - Canadian Drugs for Rheumatoid Arthritis. Plaquenil is an anti-malarial drug and contains hydroxychloroquine sulfate. It is used for treatment of malaria, auto-immune diseases like lupus and arthritis. The exact mechanism of action of Plaquenil is not known. Its action against the malarial parasites is similar to the compound chlorquine phosphate.

    Plaquenil Oral Uses, Side Effects, Interactions.
     
  11. skipjack User

    Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more.

    High Alert Contraindications/Precautions amiodarone am-ee.