Chloroquine retinopathy after drug cessation

Discussion in 'Without A Doctor Prescription' started by Aviliviastr, 08-Mar-2020.

  1. yuhan New Member

    Chloroquine retinopathy after drug cessation


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    However, in a number of patients, early retinopathy macular pigmentation sometimes with central field defects diminished or regressed completely after therapy was discontinued. Paracentral scotoma to red targets, sometimes termed PREMACULOPATHY, is indicative of early retinal dysfunction and is usually reversible with cessation of therapy. Jan 05, 2020 In general, hydroxychloroquine and chloroquine retinopathy are not reversible, and even following drug cessation, cellular damage appears to continue for a certain period of time. However, the earlier the retinopathy is recognized, the greater the chance of visual preservation. Keratopathy has been reported to be fully reversible. References Clearance of the HCQ from blood and urine can take months to years after drug cessation and visual function may continue to deteriorate slowly even after the therapy was stopped. Hydroxychloroquine Retinopathy. Chloroquine retinopathy was described for the first time in the early ’60s.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Chloroquine retinopathy after drug cessation

    Expanded spectral domain-OCT findings in the early detection., Hydroxychloroquine toxicity - EyeWiki

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  6. Hydroxychloroquine and CQ retinopathy can progress even after the drugs are stopped, although the amount of progression and the risk to vision are functions of the severity of retinopathy at the time it is detected. 5,11 It seems doubtful that this late progression of damage after stopping the drug results from a continued reservoir of the drug, although clearance from the body does take many late progression may represent a gradual decompensation of cells that were injured.

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    Chloroquine CQ has been used widely for the treatment of rheumatoid arthritis RA and significant central visual loss associated with this drug has been reported 1. Prevalence of CQ maculopathy was 13.5% among RA patients taking CQ. Chloroquine is stored in tissues such as the liver and especially the pigmented uveal ocular tissue. 10 Urinary excretion of chloroquine continues years after cessation of chloroquine. 10 These findings buttress the diagnosis of late onset chloroquine retinopathy in our patient. Importance Given the infrequent occurrence of hydroxychloroquine toxic effects, few data are available about the presenting features and long-term follow-up of patients with hydroxychloroquine retinopathy, making it difficult to surmise the clinical course of patients after cessation of drug treatment.

     
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    Chloroquine for research Cell-culture tested InvivoGen Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4.

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